Mining and visualizing uncertain data objects and named data networking traffics by fuzzy self-organizing map

Uncertainty is widely spread in real-world data. Uncertain data-in computer science-is typically found in the area of sensor networks where the sensors sense the environment with certain error. Mining and visualizing uncertain data is one of the new challenges that face uncertain databases. This paper presents a new intelligent hybrid algorithm that applies fuzzy set theory into the context of the Self-Organizing Map to mine and visualize uncertain objects. The algorithm is tested in some benchmark problems and the uncertain traffics in Named Data Networking (NDN). Experimental results indicate that the proposed algorithm is precise and effective in terms of the applied performance criteria.Peer ReviewedPostprint (published version

The use of computational intelligence for security in named data networking

Information-Centric Networking (ICN) has recently been considered as a promising paradigm for the next-generation Internet, shifting from the sender-driven end-to-end communication paradigma to a receiver-driven content retrieval paradigm. In ICN, content -rather than hosts, like in IP-based design- plays the central role in the communications. This change from host-centric to content-centric has several significant advantages such as network load reduction, low dissemination latency, scalability, etc. One of the main design requirements for the ICN architectures -since the beginning of their design- has been strong security. Named Data Networking (NDN) (also referred to as Content-Centric Networking (CCN) or Data-Centric Networking (DCN)) is one of these architectures that are the focus of an ongoing research effort that aims to become the way Internet will operate in the future. Existing research into security of NDN is at an early stage and many designs are still incomplete. To make NDN a fully working system at Internet scale, there are still many missing pieces to be filled in. In this dissertation, we study the four most important security issues in NDN in order to defense against new forms of -potentially unknown- attacks, ensure privacy, achieve high availability, and block malicious network traffics belonging to attackers or at least limit their effectiveness, i.e., anomaly detection, DoS/DDoS attacks, congestion control, and cache pollution attacks. In order to protect NDN infrastructure, we need flexible, adaptable and robust defense systems which can make intelligent -and real-time- decisions to enable network entities to behave in an adaptive and intelligent manner. In this context, the characteristics of Computational Intelligence (CI) methods such as adaption, fault tolerance, high computational speed and error resilient against noisy information, make them suitable to be applied to the problem of NDN security, which can highlight promising new research directions. Hence, we suggest new hybrid CI-based methods to make NDN a more reliable and viable architecture for the future Internet.Information-Centric Networking (ICN) ha sido recientemente considerado como un paradigma prometedor parala nueva generación de Internet, pasando del paradigma de la comunicación de extremo a extremo impulsada por el emisora un paradigma de obtención de contenidos impulsada por el receptor. En ICN, el contenido (más que los nodos, como sucede en redes IPactuales) juega el papel central en las comunicaciones. Este cambio de "host-centric" a "content-centric" tiene varias ventajas importantes como la reducción de la carga de red, la baja latencia, escalabilidad, etc. Uno de los principales requisitos de diseño para las arquitecturas ICN (ya desde el principiode su diseño) ha sido una fuerte seguridad. Named Data Networking (NDN) (también conocida como Content-Centric Networking (CCN) o Data-Centric Networking (DCN)) es una de estas arquitecturas que son objetode investigación y que tiene como objetivo convertirse en la forma en que Internet funcionará en el futuro. Laseguridad de NDN está aún en una etapa inicial. Para hacer NDN un sistema totalmente funcional a escala de Internet, todavía hay muchas piezas que faltan por diseñar. Enesta tesis, estudiamos los cuatro problemas de seguridad más importantes de NDN, para defendersecontra nuevas formas de ataques (incluyendo los potencialmente desconocidos), asegurar la privacidad, lograr una alta disponibilidad, y bloquear los tráficos de red maliciosos o al menos limitar su eficacia. Estos cuatro problemas son: detección de anomalías, ataques DoS / DDoS, control de congestión y ataques de contaminación caché. Para solventar tales problemas necesitamos sistemas de defensa flexibles, adaptables y robustos que puedantomar decisiones inteligentes en tiempo real para permitir a las entidades de red que se comporten de manera rápida e inteligente. Es por ello que utilizamos Inteligencia Computacional (IC), ya que sus características (la adaptación, la tolerancia a fallos, alta velocidad de cálculo y funcionamiento adecuado con información con altos niveles de ruido), la hace adecuada para ser aplicada al problema de la seguridad ND

Comparison between conventional pump and adsorption sampling method with passive solid phase microextraction ( SPME ) sampling to investigate changes in the concentration of benzene, toluene , and xylene ( BTX ) in urban ambient air

Background and Aims: Besides toxic effects on human, animals and plants, aromatic hydrocarbons may also be effective in the formation of photochemical smog. The measurement of these hydrocarbons, therefore, play aprominent part in evaluating their health and environmental impacts. The purpose of this study was to compare pump and adsorption sampling method with solid phase microextraction (SPME) to investigate changes in theconcentration of benzene, toluene, and xylene (BTX).Materials and Methods: SPME samplers in sampling protective holders were placed in ambient air at a relatively high traffic routes for 5 days. Sampling was carried out in two seasons. Samples were analyzed at the end of sampling period. In addition, pump and adsorption sampling method was also used to measure the concentrations of benzene, toluene, and xylene. Ethical issues were all considered in conducting the study and citation.Results: The obtained results in solid phase microextraction sampling method were compared with those obtained using the conventional pump and adsorbent method. Correlation coefficients (R2) between these methods were 0.98, 0.9 and 0.95 for benzene, toluene, and xylene, respectively. The results obtained with pump and adsorption method showed a higher values in general.Conclusion: The comparison between obtained results with these methods indicates a relatively similar values. It may be concluded that SPME sampling method can also present reliable results for the measurement of benzene,toluene and xylene concentrations in the ambient air.Keywords: Passive sampling, SPME, Benzene, Toluene, XyleneFor downloading the full text please click here

Outpatient Transurethral Cystolithotripsy of Large Bladder Stones by Holmium Laser

Introduction: To assessment of the efficacy and safety of transurethral cystolithotripsy of large bladder stones by holmium laser in the outpatient setting.Methods: In a prospective study, 48 consecutive adult patients with large bladder stones, were enrolled for transurethral cystolithotripsy. Patients older than 18 years, with bladder stones larger than 2 cm were enrolled. Urethral stricture, active urinary infection, and any anesthetic contraindications for operation, were the exclusion criteria. Demographic characteristics of patients, outcomes and complications related to operation and post operation period, were recorded.Results: Patients mean age was 46 ± 7.3 years. Male to female ratio was 45/3. Mean body mass index of patients was 28.5 ± 3.5. Mean stone size was 3.7 ± 1.6 cm. Mean operation time was 43.5 ± 15.5 minutes. Nearly complete stone clearance (98.5%) was achieved in all patients. Mean hospital stay was 6.5 ± 1.3 hours. No major complications were seen. Mean visual analog pain score (VAS) was 4.2 ± 2.1 and 1.4 ± 0.6, during and 1 hour after operation, respectively. During follow up of 22.4 ± 12.5 months, recurrence of bladder stone was not seen. No case of urethral stricture was detected.Conclusion: Transurethral holmium laser lithotripsy is an effective and safe alternative in selected patients with large bladder stones. This procedure can be easily performed in the outpatient setting

Promjene u RF-amidu srodnom peptidu-3 hipotalamusa i ekspresijama gena Kiss1 tijekom spermatogeneze kod štakora u uvjetima kroničnog stresa.

The effects were evaluated of chronic stress and the glucocorticoid receptor antagonist (RU486) on mRNA expressions of RF-amide related peptide-3 (RFRP-3) in the dorsomedial hypothalamic nucleus (DMH) and Kiss1 in the arcuate nucleus (ARC) of male rats. Twenty-four male rats were allocated to four equal sized groups: the stress, RU486, stress/RU486, and control groups. In the stress group the rats were restrained 1 hour/day for 12 days. In the RU486 group, the rats were injected with RU486 for 12 days. In the stress/RU486 group, the rats were injected with RU486 1 hour before the stress process for 12 days. Relative expressions of RFRP-3 and Kiss1 mRNAs were determined using real-time PCR. The relative expression of RFRP-3 mRNA in the stress group was higher than that in the RU486 and control rats. The relative expression of RFRP-3 mRNA did not differ between the stress group and the stress/RU486 rats. Furthermore, the relative expressions of Kiss1 mRNA in the stress, RU486, and stress/RU486 groups were less than that of the control rats. The relative expression of Kiss1 mRNA did not differ between the stress, RU486, and stress/RU486 groups. In conclusion, dysfunction in male rat fertility caused by the chronic stress may be the result of the increase in REFP-3 and the decrease in Kiss1 mRNA expression.Istražen je učinak kroničnog stresa i antagonista glukokortikoidnog receptora (RU486) na ekspresiju mRNA RF-amidu srodnog peptida-3 (RFRP-3) u dorzomedijalnoj jezgri hipotalamusa (DMH), te na ekspresije gena Kiss1 u arkuatnom nukleusu (ARC) štakora. Dvadeset i četiri štakora bila su raspodijeljena u četiri jednake skupine: stresna skupina, RU486 skupina, stresna/RU486 skupina i kontrolna skupina. U stresnoj skupini štakori su 12 dana bili obuzdani tijekom jednog sata dnevno. U skupini RU486, štakorima je tijekom 12 dana bio primijenjivan RU486. U skupini stres/RU486, štakorima je tijekom 12 dana apliciran RU486 jedan sat prije postupka obuzdavanja. Relativne ekspresije RFRP-3 i Kiss1 mRNA određene su lančanom reakcijom polimerazom u stvarnom vremenu. Relativna ekspresija RFRP-3 mRNA u stresnoj skupini bila je veća nego u skupini RU486 i kontrolnoj skupini. Relativna ekspresija RFRP-3 mRNA nije bila različita između stresne skupine i stres/RU486 skupine. Nadalje, relativne ekspresije Kiss1 mRNA u stresnoj skupini, skupini RU486, i stresnoj skupini/RU486 bile su manje u odnosu na kontrolnu skupinu. Relativna ekspresija Kiss1 mRNA nije se razlikovala između stresne skupine, skupineRU486 i stresne skupine/RU486. Zaključno, disfunkcija plodnosti kod štakora izloženih kroničnom stresu može biti uzrokovana putem povećane ekspresije RFRP-3 i smanjene ekspresije Kiss1 mRNA

The Role of Nanomaterials in the Treatment of Diseases and Their Effects on the Immune System

Nanotechnology has been widely exploited in recent years in various applications. Different sectors of medicine and treatment have also focused on the use of nanoproducts. One of the areas of interest in the treatment measures is the interaction between nanomaterials and immune system components. Engineered nanomaterials can stimulate the inhibition or enhancement of immune responses and prevent the detection ability of the immune system. Changes in immune function, in addition to the benefits, may also lead to some damage. Therefore, adequate assessment of the novel nanomaterials seems to be necessary before practical use in treatment. However, there is little information on the toxicological and biological effects of nanomaterials, especially on the potential ways of contacting and handling nanomaterials in the body and the body response to these materials. Extensive variation and different properties of nanomaterials have made it much more difficult to access their toxicological effects to the present. The present study aims to raise knowledge about the potential benefits and risks of using the nanomaterials on the immune system to design and safely employ these compounds in therapeutic purposes

Alterations in juvenile diploid and triploid African catfish skin gelatin yield and amino acid composition: effects of chlorpyrifos and butachlor exposures

Skin is a major by-product of the fisheries and aquaculture industries and is a valuable source of gelatin. This study examined the effect of triploidization on gelatin yield and proximate composition of the skin of African catfish (Clarias gariepinus). We further investigated the effects of two commonly used pesticides , chlorpyrifos (CPF) and butachlor (BUC), on the skin gelatin yield and amino acid composition in juvenile full-sibling diploid and triploid African catfish. In two separate experiments, diploid and triploid C. gariepinus were exposed for 21 days to graded CPF [mean measured: 10, 16, or 31 mg/L] or BUC concentrations [Mean measured: 22, 44, or 60 mg/L]. No differences in skin gelatin yield, amino acid or proximate compositions were observed between diploid and triploid control groups. None of the pesticide treatments affected the measured parameters in diploid fish. In triploids, however, gelatin yield was affected by CPF treatments while amino acid composition remained unchanged. Butachlor treatments did not alter any of the measured variables in triploid fish. To our knowledge, this study is the first to investigate changes in the skin gelatin yield and amino acid composition in any animal as a response to polyploidization and/or contaminant exposure